The tooth development begins in the 6th week as U-shaped thickenings of the oral epithelium. These structures, called dental laminae, are placed along the length of the upper and lower jaw. Dental laminae soon give rise to the ten proliferation centers called tooth buds which penetrate into underlying mesenchyme. Tooth buds soon develop a cup-shaped enamel organ due to the invagination of the mesenchyme condensation called the dental papilla. The enamel organ consists of the inner and outer enamel epithelium and enamel reticulum, while dental papilla contains dense collection of stelate cells that will give rise to the most of the tooth proper, including the pulp cavity, dentin and blood supply for the teeth. Enamel organ and dental papilla are surrounded by a mesenchyme condensation called the dental sac.
Cells of the inner enamel epithelium differentiate into ameloblasts, which produce the enamel.